Skin neurogenic inflammation
نویسندگان
چکیده
منابع مشابه
Neurogenic inflammation in human and rodent skin.
The combination of vasodilation and protein extravasation following activation of nociceptors has been termed "neurogenic inflammation." In contrast to rodents, no neurogenic protein extravasation can be elicited in healthy human skin. Dermal microdialysis has considerably increased our knowledge about neurogenic inflammation in human skin, including the involvement of mast cells.
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Neurogenic inflammation is involved in skin inflammation. It is hypothesized that it is involved in the pathogenesis of the common chronic cutaneous vascular disorder rosacea, but the exact mechanism of action is currently unknown. Transient receptor potential vanilloid 1 (TRPV1) and ankyrin 1 (TRPA1) are widely expressed on primary sensory neuron endings and non-neuronal cells such as keratino...
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Tumor-promoting phorbol esters are potent inflammatory agents for mouse skin, and the potential mechanistic role of inflammation in tumor promotion is under active investigation. We have shown previously that resiniferatoxin, a uniquely irritant phorbol-related diterpene, acts as a capsaicin analogue to induce and then to block neurogenic inflammation. We report here that pretreatment of CD-1 m...
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William Meggs's recent article, "Neuro-genic Inflammation and Sensitivity to Environmental chemicals" (EHP 101:234-238), provides a useful introduction to a rapidly growing area of knowledge in physiology and posits a number of interesting hypotheses regarding the health effects of airborne chemicals. Some specific technical points, however, merit comment. Meggs describes the common chemical se...
متن کاملNeurogenic inflammation and allergy
Neurogenic inflammation encompasses a series of vascular and non-vascular inflammatory responses, triggered by the activation of primary sensory neurons with a subsequent release of inflammatory neuromediators, resulting in a neurally mediated immune inflammation. Neuromediators are mainly released from neurons. Immune and/or structural cells are secondary sources of these mediators during immu...
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ژورنال
عنوان ژورنال: Seminars in Immunopathology
سال: 2018
ISSN: 1863-2297,1863-2300
DOI: 10.1007/s00281-018-0675-z